Mark Kotter鈥檚 synthetic biology team at Bit Bio has already won lots of local recognition in the UK for its tech for precision reprogramming of stem cells at an industrial scale. Now they have a jolt of cash from some marquee US investors to fuel the work and drive some added global panache for the biotech鈥檚 profile.
Mark Kotter, University of Cambridge
The money 鈥� $41.5 million 鈥� isn鈥檛 likely to stir much attention these days as billions in cash continue to course through the industry. These investor names, though, as well as their interest in cell therapy 2.0, should create a tingle of excitement.
There鈥檚 Rick Klausner, the ex-chief of the National Cancer Institute who鈥檚 gone on to push new entrepreneurial efforts on cell therapies at Lyell, where the Juno co-founder has been steadily widening a network of collaborators 鈥� along with the biotechs Klausner鈥檚 been investing in. Bob Nelsen at Arch is on board, one of a slew of deals where he鈥檚 aligned himself along the revolutionary edge of drug R&D. And there鈥檚 Jim Tananbaum, the CEO at Foresite Capital.
What drew them in was the Cambridge University鈥檚 platform approach to coding for cells at an industrial scale, making it possible to relatively quickly gin up batches of specific cells that come out with enhanced features.
From left to right: Rick Klausner Lyell; Bob Nelsen ARCH; Jim Tananbaum
Early on, Kotter鈥檚 crew had focused on things like developing vastly superior cells for preclinical work. But as anyone with a passing interest in the field will notice, these investors are digging in deep on cell therapy 2.0. And it鈥檚 easy to explain why they鈥檙e intrigued by the UK company.
Right now, cell therapy 1.0 includes a mix of cells that are often 鈥渘ot in very good shape,鈥� Kotter tells me. 鈥淥nly a subset of cells are therapeutic, some dangerous,鈥� he adds, triggering severe adverse events that hospitalizes and still sometimes kills patients.
Provide a scalable approach to creating cells with a much better, far more consistent profile 鈥� capable of far greater durability 鈥� and you will command the attention of a who鈥檚 who in cancer R&D.
Klausner鈥檚 take is loaded with praise for the potential disruption involved.
鈥淏it Bio is based on beautiful science. The company鈥檚 technology has the potential to bring the long-awaited precision and reliability of engineering to the application of stem cells. Bit Bio鈥檚 approach represents a paradigm shift in biology that will enable a new generation of cell therapies, improving the lives of millions.鈥�
That鈥檚 a tall order. And now Kotter and the team have the cash to make its reality.