Glial cells include astrocytes, microglia, oligodendrocytes, and associated precursor cells that enable the brain to function. Once known as nervenkitt (a German word meaning 鈥渘erve glue鈥), glial cells are the 鈥済lue鈥 that holds the nervous system together by facilitating neuronal signalling, enabling tissue plasticity, providing neuronal support and axonal integrity, metabolism, and protecting neurons from would-be pathogens [1,2].
In recent years, a greater appreciation for the role of glial cells in neuronal homeostasis has helped expose potential therapeutic targets in neurodegenerative disease. Glial cells play a complex, enigmatic role in the development and progression of Alzheimer鈥檚 disease, Parkinson鈥檚 disease, and others. Many research projects are now focussing on understanding the therapeutic potential of targeting glial cells in neurodegenerative disease [2].
With access to a consistent and defined source of human glial cell types, researchers can build the complex, physiologically relevant glial cell culture models that are sorely needed in for drug discovery. Whether co-cultured with neurons, as part of a multi-cellular glial-neuronal culture, or used to build three-dimensional tissue models, ioCells are well suited for tissue and neurodegenerative disease modelling; for drug target identification and validation; as well as drug screening among many other uses.
Take your research to the next level with our ioCells below.
Explore the implication of glial cells in neurodegenerative diseases in this webinar featuring , Senior Research Investigator, .
V6
2024
不良研究所
Dr Brian Gill, MD | Assistant Professor of Neurological Surgery| Columbia University Irving Medical Center
Dr Tony Oosterveen | Principal Scientist and CNS Lead, Neurobiology | 不良研究所
不良研究所
Whitehouse, et al
JoVE Journal of Visualized Experiments
2023
Using ioGlutamatergic Neurons
V2
不良研究所
2024
Mark Kotter | CEO and founder | 不良研究所
Marius Wernig | Professor Departments of Pathology and Chemical and Systems Biology | Stanford University
Madeleine Garrett | Field Application Specialist | 不良研究所
Dr Matthias Pawlowski | Head, Dementia-Sensitive Hospital | University of M眉nster
Dr Malathi Raman | Senior Product Manager | 不良研究所
Dr Alex Davenport | Senior Scientist | 不良研究所
Talk at ELRIG Cell & Gene Therapy
2021
Davenport A, Frolov T & Kotter M
Drug Discovery World
2020
1. J盲kel S, Dimou L. (2017) Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation. 2017 Feb 13;11:24. doi: . PMCID: PMC5303749 PMID:
2. Hanslik K, Marino K, Ulland T. (2021) Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease. . 2021 Aug 31;15:718324. doi: . PMCID: PMC8439422 PMID: