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Human iPSC-derived glial cells

Consistent, defined and scalable human iPSC-derived glial cell types for neurodegenerative disease research

Glial cells include astrocytes, microglia, oligodendrocytes, and associated precursor cells that enable the brain to function. Once known as nervenkitt (a German word meaning 鈥渘erve glue鈥�), glial cells are the 鈥済lue鈥� that holds the nervous system together by facilitating neuronal signalling, enabling tissue plasticity, providing neuronal support and axonal integrity, metabolism, and protecting neurons from would-be pathogens [1,2]. 

In recent years, a greater appreciation for the role of glial cells in neuronal homeostasis has helped expose potential therapeutic targets in neurodegenerative disease. Glial cells play a complex, enigmatic role in the development and progression of Alzheimer鈥檚 disease, Parkinson鈥檚 disease, and others. Many research projects are now focussing on understanding the therapeutic potential of targeting glial cells in neurodegenerative disease [2]. 

With access to a consistent and defined source of human glial cell types, researchers can build the complex, physiologically relevant glial cell culture models that are sorely needed in for drug discovery. Whether co-cultured with neurons, as part of a multi-cellular glial-neuronal culture, or used to build three-dimensional tissue models, ioCells are well suited for tissue and neurodegenerative disease modelling; for drug target identification and validation; as well as drug screening among many other uses. 

Take your research to the next level with our ioCells below.

ioWild Type Cells

ioWild Type Cells

ioAstrocytes cat no | ioEA1093

ioWild Type Cells

ioMicroglia | Female cat no | io1029

ioWild Type Cells

ioMicroglia | Male cat no | io1021

ioWild Type Cells

ioOligodendrocyte-like cells cat no | io1028

Engineered to meet your workflow with our toolkit of ioDisease Model Cells,  ioTracker Cells and CRISPR-Ready ioCells

CRISPR-Ready ioCells

CRISPRko-Ready ioOligodendrocyte-like cells cat no | io1095

ioTracker Cells

GFP ioMicroglia | Male cat no | io1096

CRISPR-Ready ioCells

CRISPRko-Ready ioMicroglia Male cat no | io1094

ioDisease Model Cells

ioMicroglia P2RY12 null/WT cat no | io6015

ioDisease Model Cells

ioMicroglia P2RY12 null/null cat no | io6012

ioDisease Model Cells

ioMicroglia TREM2 R47H/WT cat no | io1038

ioDisease Model Cells

ioMicroglia TREM2 R47H/WT cat no | io1038

ioDisease Model Cells

ioMicroglia APOE 4/3 C112R/WT cat no | io1033

ioDisease Model Cells

ioMicroglia APOE 4/4 C112R/C112R cat no | io1032

CRISPR-Ready ioCells

CRISPRa-Ready ioGlutamatergic Neurons cat no | io1099

CRISPR-Ready ioCells

NEW! CRISPRi-Ready ioMicroglia Male cat no | io1103

Human iPSC-based models of glial cells for studying neurodegenerative disease

Explore the implication of glial cells in neurodegenerative diseases in this webinar featuring , Senior Research Investigator, . 

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Product resources

Application note

Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons

V1
2024
不良研究所
Inventia

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Technical note

Enhancement of MBP expression in human iPSC-derived oligodendrocyte-like cells by optimising db-cAMP concentration in media

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Brochure

ioGlutamatergic Neurons

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Brochure

ioOligodendrocyte-like cells

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Brochure

ioAstrocytes

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Poster

An iPSC-derived neuroinflammation/neurotoxicity in vitro model of neurons and glial cells

Bsibsi et al.

Courtesy of Charles River Laboratories

2024

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Poster

Driving experimental reproducibility and lot-to-lot biological consistency in human iPSC-derived cells enabled by opti-ox technology

Newman et al.

不良研究所

2024

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Poster

Rapid and consistent generation of human iPSC-derived oligodendrocyte-like cells using opti-ox technology

Herrera-Vaquero et al.

不良研究所

2024

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Poster

Establishment and validation of an in vitro co-culture model to study myelination using human iPSC-derived glutamatergic neurons and oligodendrocytes

Bsibsi et al.

Courtesy of Charles River Laboratories

2024

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Poster

In vitro model to study demyelinating disease using human OPC- and oligodendrocyte-like cells generated by deterministic cell programming

Veteleanu et al.

不良研究所

2025

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Publication

Reprogramming the stem cell for a new generation of cures

Davenport A, Frolov T & Kotter M

Drug Discovery World

2020

 

 

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Publication

3D bioprinting of iPSC neuron-astrocyte coculture

Whitehouse, et al
JoVE Journal of Visualized Experiments 
2023

Using ioGlutamatergic Neurons

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Talk

Cellular reprogramming to enable the precise and scalable manufacturing of human cells for therapeutic applications

Dr Alex Davenport | Senior Scientist | 不良研究所

Talk at ELRIG Cell & Gene Therapy

2021

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Talk

Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models

Madeleine Garrett | Field Application Specialist | 不良研究所

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User manual

ioOligodendrocyte-like cells user manual | 不良研究所

V2

不良研究所

2024

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User manual

ioAstrocytes user manual | 不良研究所

DOC-1240 v8.0

2025

不良研究所

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User manual

CRISPRko-Ready ioOligodendrocyte-like cells user manual | 不良研究所

V1
2025
不良研究所

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Video tutorial

How to culture ioOligodendrocyte-like cells

Prachi Bhagwatwar鈥嬧�嬧�嬧�� | 鈥婻esearch Assistant | 不良研究所

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Webinar

Alzheimer鈥檚 Disease Pathogenesis: Emerging Role of Microglia | 不良研究所

Dr Matthias Pawlowski | Head, Dementia-Sensitive Hospital | University of M眉nster

Dr Malathi Raman | Senior Product Manager | 不良研究所

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Webinar

Rethinking Developmental Biology With Cellular Reprogramming | 不良研究所

Mark Kotter | CEO and founder | 不良研究所

Marius Wernig | Professor Departments of Pathology and Chemical and Systems Biology |  Stanford University

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References

1. J盲kel S, Dimou L. (2017) Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation. 2017 Feb 13;11:24. doi: . PMCID: PMC5303749  PMID:

2. Hanslik K, Marino K, Ulland T. (2021) Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease. . 2021 Aug 31;15:718324. doi: . PMCID: PMC8439422  PMID:

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