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Human iPSC-derived glial cells

Consistent, defined and scalable human iPSC-derived glial cell types for neurodegenerative disease research

Glial cells include astrocytes, microglia, oligodendrocytes, and associated precursor cells that enable the brain to function. Once known as nervenkitt (a German word meaning 鈥渘erve glue鈥), glial cells are the 鈥済lue鈥 that holds the nervous system together by facilitating neuronal signalling, enabling tissue plasticity, providing neuronal support and axonal integrity, metabolism, and protecting neurons from would-be pathogens [1,2]. 

In recent years, a greater appreciation for the role of glial cells in neuronal homeostasis has helped expose potential therapeutic targets in neurodegenerative disease. Glial cells play a complex, enigmatic role in the development and progression of Alzheimer鈥檚 disease, Parkinson鈥檚 disease, and others. Many research projects are now focussing on understanding the therapeutic potential of targeting glial cells in neurodegenerative disease [2]. 

With access to a consistent and defined source of human glial cell types, researchers can build the complex, physiologically relevant glial cell culture models that are sorely needed in for drug discovery. Whether co-cultured with neurons, as part of a multi-cellular glial-neuronal culture, or used to build three-dimensional tissue models, ioCells are well suited for tissue and neurodegenerative disease modelling; for drug target identification and validation; as well as drug screening among many other uses. 

Take your research to the next level with our ioCells below.

Human iPSC-based models of glial cells for studying neurodegenerative disease

Explore the implication of glial cells in neurodegenerative diseases in this webinar featuring , Senior Research Investigator, . 

bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry

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How to culture ioOligodendrocyte-like cells Video tutorial
How to culture ioOligodendrocyte-like cells
Prachi Bhagwatwar鈥嬧嬧嬧 | 鈥婻esearch Assistant | 不良研究所
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Dr Tony Oosterveen | Principal Scientist and CNS Lead, Neurobiology | 不良研究所

 

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References

1. J盲kel S, Dimou L. (2017) Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation. 2017 Feb 13;11:24. doi: . PMCID: PMC5303749  PMID:

2. Hanslik K, Marino K, Ulland T. (2021) Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease. . 2021 Aug 31;15:718324. doi: . PMCID: PMC8439422  PMID:

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