Poster
Development of human iPSC-derived hepatocytes for drug discovery, translational research and toxicity testing
You will learn:
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ioHepatocytes provide a scalable alternative to primary human hepatocytes, displaying classic cobblestone morphology and expressing key markers like ALB and HNF4A with high lot-to-lot consistency
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The cells demonstrate essential metabolic functions such as glycogen storage, lipid accumulation, and bile canaliculi formation for disease modelling
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Advanced toxicology applications are supported as ioHepatocytes express phase I鈥揑II drug metabolism genes and functional CYP450 enzymes, matching the toxic response of primary cells for predictive safety testing