Publication
CRISPR-Cas9 knockout screen in iPSC-derived Neurons identifies new Alzheimer’s disease druggable target
Read the publication to explore:
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A genetic screen in human iPSC-derived cortical neurons that identified key modulators of endoplasmic reticulum (ER) stress
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The discovery of KAT2B as a therapeutic target and the neuroprotective effects of its inhibitor, L-Moses
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Evidence that L-Moses reduces stress signals and prevents cell death in both cortical and dopaminergic neurons
- How CRISPRko-Ready ioGlutamatergic Neurons were used