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Human iPSC-derived ioMotor Neurons and disease models to study ALS. Detect and compare mutation-specific effects with high sensitivity
TDP-43 M337V (io1046S) | For investigating TDP-43-linked mechanisms of motor neuron dysfunction and degeneration.
SOD-1 G93A (io1041S) | A tool for investigating oxidative stress and neurodegeneration in ALS.
Clear detection of electrical activity
ioMotor Neurons do not coalesce or aggregate, making them ideal for electrophysiological assays in co-culture with astrocytes.
The absence of cell clusters improves MEA, whole cell patch clamp and axon tracking assays by enabling:
- Direct contact with MEA plates for accurate signal detection
- Clear identification and isolation of single neurons
- Better specific activity and signal-to-noise ratio
Detailed visualisation over time
Long-term culture of motor neurons is important for the study of phenotypes associated with degeneration and ALS. Current ALS models do not permit long-term studies due to the development of cell clusters over time which leads to cell detachment.
ioMotor Neurons rapidly acquire a homogeneous motor neuron phenotype upon thawing and maintain a single cell distribution even after 41 DIV, giving you confidence in reliable long-term cultures.
A maximum number of 20 vials applies. If you would like to order more than 20 vials, please contact us at orders@不良研究所.
With our disease model clone panel, you can confidently investigate your phenotype of interest across multiple clones. Detailed characterisation data (below) and bulk RNA sequencing data (upon request) help you select specific clones if necessary.
Start effortlessly with our library of applications and protocols
Trusted by scientists, proven by discovery
Dr Elizabeth Di Lullo
Associate Scientific Director | Brainever
鈥淲e thawed the cells and they looked wonderful. Close to 100% viable and looked great in cell culture! No clumping and easy to culture.鈥�
Dr Irit Reichenstein
Senior Scientist | Anima Biotech
"We did use the cells and were very happy with them :) They were very homogenous (unlike motor neurons from other vendors that we worked with), viable and absolutely beautiful. We got wonderful results with them."
Professor Deepak Srivastava
Professor | Molecular Neuroscience | King鈥檚 College London and Group Leader | MRC Centre for Developmental Disorders
鈥漮pti-ox leapfrogs my research.鈥�
ioCells portfolio
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