不良研究所

Alzheimer's disease microglia pack

3-vial bundle | ioMicroglia WT, APOE C112R, and TREM2 R47H

Use discount code ADMICPACK 

 

nanolive-microglia-mono-phago
AB42 Percentage positive- Male WT ApoE (1)
nanolive-microglia-mono-phago
AB42 Percentage positive- Male WT ApoE (1)

Human iPSC-derived ioMicroglia and models to study Alzheimer's disease. Detect and compare mutation-specific effects with high sensitivity

ioMicroglia (io1021S, io1029S, or io1096S) | Perform key immune functions, including phagocytosis and cytokine secretion.

APOE C112R (io1032S) | Engineered to investigate the impact of the APOE 4/4 allele in Alzheimer's disease.

TREM2 R47H (1035) | Engineered to investigate the effect of the mutant TREM2 protein in Alzheimer's disease. 

Place your order

Add to basket: 

Request a quote for your pack
nanolive-microglia-mono-phago

Key functions with consistency

ooMicroglia selectively phagocytose pHrodo Red-labelled Zymosan particles. The red fluorescence indicates successful engulfment, triggered by a pH shift.

AB42 Percentage positive- Male WT ApoE (1)

Key phagocytic and cytokine secretion functions

Day 10 male donor-derived ioMicroglia (io1021S) and the Alzheimer's disease model ioMicroglia APOE 4/4 (io1032S) were incubated with 125nM Hilexa488-Amyloid Beta1-42 for 20 hours. Images were acquired every 30 mins on the Incucyte庐 and percentage of phagocytosis calculated based on fluorescence. Three technical replicates were performed.

See complete data sets

A maximum number of 20 vials applies. If you would like to order more than 20 vials, please contact us at orders@不良研究所.

Confidently investigate your phenotype of interest across multiple clones with our disease model clone panel. Detailed characterisation data (below) and bulk RNA sequencing data (upon request) help you select specific clones if required.

Start effortlessly with our library of applications and protocols

Get started now
gluts-mg-co-culture protocol

Neuron-microglia co-cultures

Study neuroinflammation, excitatory signalling, and neurodegenerative disease functional co-cultures.

Co-culture protocol
MG detachment protocol (1)

Cell detachment

For re-seeding experiments such as establishing neuron-microglia co-cultures.

Cell detachment protocol
MG user manual preview

User protocol

With a single protocol easily culture ioMicroglia and any of the disease models.

User manual

Eligible products

ioMicroglia | Male ioWild Type Cells
ioMicroglia | Male cat no | io1021
ioMicroglia APOE 4/4 C112R/C112R ioDisease Model Cells
ioMicroglia APOE 4/4 C112R/C112R cat no | io1032
ioMicroglia TREM2 R47H/R47H ioDisease Model Cells
ioMicroglia TREM2 R47H/R47H cat no | io1035
ioMicroglia | Female ioWild Type Cells
ioMicroglia | Female cat no | io1029
New! GFP ioMicroglia | Male ioTracker Cells
New! GFP ioMicroglia | Male cat no | io1096

Trusted by scientists, proven by discovery

An image of Matteo Zanella, PhD

Matteo Zanella, PhD

Associate Research Leader | Charles River

"At Charles River we used 不良研究所 ioMicroglia in several projects. We are very satisfied with their performances, as they efficiently and robustly recapitulate both morphological and functional properties of microglia cells"

An image of Professor Deepak Srivastava

Professor Deepak Srivastava

Professor | Molecular Neuroscience | King鈥檚 College London and Group Leader | MRC Centre for Developmental Disorders

鈥漮pti-ox leapfrogs my research.鈥�

ioCells portfolio

View product catalogue
ioSkeletal Myocytes_for partners module

ioWild Type Cells

ioWild Type Cells are defined, easy-to-use, functional iPSC-derived human cells from a healthy donor background that are ready for fundamental research and drug discovery experimentation within days.
Explore now
Discover ioCells portfolio ICC ioDisease model cells

ioDisease Model Cells

ioDisease Model Cells are ioWild Type Cells engineered to contain disease-relevant mutations. ioDisease Model Cells and ioWild Type Cells form an isogenic pair allowing scientists to make true comparisons.
Explore now
bb-CRISPR-ready-card

CRISPR-Ready ioCells

CRISPR-Ready ioCells are human iPSC-derived cells constitutively expressing Cas9 nuclease for rapid gene knockout generation. 
Explore now
bb-iotracker-cards

ioTracker Cells

ioTracker Cells are human iPSC-derived cells constitutively expressing a fluorescent protein for easy visualisation, tracking, and isolation of human cells in live-cell imaging assays.
Explore now

Deterministic cell programming

It's what makes ioCells unique.

All ioCells are powered by opti-ox鈩�, a deterministic cell programming technology that resolves the inconsistency of current technologies including classical stem cell differentiation and cellular reprogramming. With opti-ox, we can generate human cells with unmatched precision, consistency and scalability. 

Watch the video to find out more.

*T&Cs: Each bundle includes 1 small vial of ioMicroglia (io1021S, io1029S, or io1096S), ioMicroglia APOE 4/4 C112R/C112R (io1032S), and ioMicroglia TREM2 R47H/R47H (io1035S). Offer subject to availability. A maximum of 5 packs may be purchased per order. This offer is intended for limited-use research and cannot be used for bulk purchasing. Repeat orders may be placed at a later time, subject to availability. Pricing and contents are subject to change without notice. Standard 不良研究所 terms of sale apply.