Functional co-cultures of human neurons and microglia for studying neuroinflammation, excitatory signalling, and neurodegenerative disease
Includes a co-culture protocol for building human-relevant models
ioGlutamatergic Neurons (io1001S) | Rapidly maturing, functional, consistent excitatory neurons with no inhibitory neurons.
ioMicroglia (io1021S, io1029S, io1096S) | Perform key immune functions, including phagocytosis and cytokine secretion.
ioMicroglia retain phagocytic function in co-culture with ioGlutamatergic Neurons
ioMicroglia selectively phagocytose pHrodo Red-labelled Zymosan particles. The red fluorescence indicates successful engulfment, triggered by a pH shift, without affecting neuron morphology.
ioGlutamatergic Neurons show enhanced network activity in co-culture with ioMicroglia
Co-cultures showed increased network correlation and longer burst durations. Data are presented as mean 卤 SEM, n = 3鈥�12 replicates.
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A maximum number of 20 vials applies. If you would like to order more than 20 vials, please contact us at orders@不良研究所.
Confidently investigate your phenotype of interest across multiple clones with our disease model clone panel. Detailed characterisation data (below) and bulk RNA sequencing data (upon request) help you select specific clones if required.
Co-culture protocol included for ioGlutamatergic Neurons and ioMicroglia
Trusted by scientists, proven by discovery
Dr Simone Mader
Junior Group Leader | Institute of Clinical Neuroimmunology | LMU Munich
"不良研究所鈥檚 ioGlutamatergic Neurons provide a human model that is well-characterised, batch-consistent, and easy to use with our limited neuronal culture experience. We are grateful for the support from the 不良研究所 team and are now preparing our data for publication."
Matteo Zanella, PhD
Associate Research Leader | Charles River
"At Charles River we used 不良研究所 ioMicroglia in several projects. We are very satisfied with their performances, as they efficiently and robustly recapitulate both morphological and functional properties of microglia cells"
Dr Elizabeth Di Lullo
Associate Scientific Director | Brainever
鈥淲e thawed the cells and they looked wonderful. Close to 100% viable and looked great in cell culture! No clumping and easy to culture.鈥�
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